L-tert-Leucine-Derived AmidPhos-Silver(I) Chiral Complexes for the Asymmetric [3+2] Cycloaddition of Azomethine Ylides

被引：15

作者：

Zhou, Zhipeng ^{[1
]}

Zheng, Xiaojun ^{[1
]}

Liu, Jialin ^{[1
]}

Li, Jinlei ^{[1
]}

Wen, Pushan ^{[1
]}

Wang, Haifei ^{[1
]}

机构：

[1] Hunan Univ Technol, Coll Life Sci & Chem, Zhuzhou 412007, Hunan, Peoples R China

来源：

SYNLETT | 2017年 / 28卷 / 08期

关键词：

L-tert-leucine; amidophosphane; silver(I); 3+2] cycloaddition; azomethine ylide; ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; IMINO ESTERS; FERROCENYL P; S-LIGANDS; CATALYSTS; CONSTRUCTION; NITROALKENES; DERIVATIVES; PYRROLIDINES; REVERSAL; LIGANDS;

D O I：

10.1055/s-0036-1588137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The L-tert-leucine-derived AmidPhos/silver(I) catalytic system has been developed for the asymmetric [3+2] cycloaddition of azomethine ylides with electronic-deficient alkenes with or without Et3N. Under optimal conditions, highly functionalized endo-4-pyrrolidines were obtained with modest to high yields (up to 99% yield) and enantioselectivities (up to 98% ee).

引用

页码：999 / 1003

页数：5

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