Quantitative sensing of nanoscale colloids using a microchip Coulter counter

被引:137
作者
Saleh, OA [1 ]
Sohn, LL [1 ]
机构
[1] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA
关键词
D O I
10.1063/1.1419224
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
We have fabricated a microchip Coulter counter on a quartz substrate, and have used it to detect individual nanoscale colloidal particles with a sensitivity proportional to each particle's size. We demonstrate the ability of this device to sense colloids as small as 87 nm diameter, and to distinguish between colloids whose diameters differ by less than 10%. Further reductions in the pore size, easily done with current nanofabrication techniques, make our device applicable to measuring biological macromolecules, such as DNA and proteins. (C) 2001 American Institute of Physics.
引用
收藏
页码:4449 / 4451
页数:3
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