Two New Antimicrobial Metabolites from the Endophytic Fungus, Seimatosporium sp.

被引：0
作者：
Hussain, Hidayat [1 ,3 ]
Krohn, Karsten [1 ]
Schulz, Barbara [2 ]
Draeger, Siegfried [2 ]
Nazir, Mamona [4 ]
Saleem, Muhammad [4 ]
机构：
[1] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany
[2] Tech Univ Carolo Wilhelmina Braunschweig, Inst Mikrobiol, D-31806 Braunschweig, Germany
[3] Univ Nizwa, Coll Arts & Sci, Dept Biol Sci & Chem, Birkat Al Mouz 616, Nizwa, Oman
[4] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur, Pakistan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 03期
关键词：
Natural products; endophytic fungi; Seimatosporium sp; antimicrobial activity; SECONDARY METABOLITES;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the H-1 and C-13 NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae.
引用
收藏
页码：293 / 294
页数：2
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