Association between polymorphisms of cytokine genes and the rate of multiple sclerosis progression

被引：0
|
作者：
Korobko, D. S. [1 ]
Kudryavtseva, E. A. [1 ]
Malkova, N. A. [1 ]
Filipenko, M. L. [1 ]
机构：
[1] State Novosibirsk Reg Clin Hosp, Reg Ctr Multiple Sclerosis, Novosibirsk, Russia
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2012年 / 112卷 / 02期
关键词：
multiple sclerosis; genetics; prediction; SUSCEPTIBILITY; PREDISPOSITION; DISABILITY; SEARCH; LOCUS; CD40;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A genetic predisposition due to the polygenic system responsible for the formation of immune response plays a key role in the development of multiple sclerosis. We genotyped the following polymorphisms: TNF alpha (rs1800629), TNFRSF1A (rs4149584), CD40 (rs6074022 and rs11086998) using TaqMan technology. The significant genotype effect on the disability index on EDSS and rate of MS progression was found. The association between GA and AA TNFa genotypes and higher average annual frequency of exacerbations was revealed. Genotypes CC (rs6074022) and GG (rs11086998) were associated with the higher disability level. Genotype CC (rs11086998) was associated with the higher rate of MS progression. The results may be used as potential predictors of high rate of MS progression and allow to tailor treatment on early stages of the disease.
引用
收藏
页码：9 / 15
页数：7
相关论文
共 50 条
  • [1] Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate
    Hladikova, Magdalena
    Vasku, Anna
    Stourac, Pavel
    Benesova, Yvonne
    Bednarik, Josef
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 303 (1-2) : 31 - 34
  • [2] Association between cytokine gene polymorphisms and cognitive functions in relapsing-remitting multiple sclerosis
    Trenova, A. G.
    Slavov, G. S.
    Manova, M. G.
    Zahariev, Z. I.
    Miteva, L. D.
    Stanilova, S. A.
    MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 825 - 825
  • [3] The association between menopause and the multiple sclerosis progression
    de Caneda, M. A.
    Silva, C. B.
    de Vecino, M. C.
    MULTIPLE SCLEROSIS JOURNAL, 2022, 28 (1_SUPPL) : 113 - 113
  • [4] Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis
    Schmidt, S
    Barcellos, LF
    DeSombre, K
    Rimmler, JB
    Lincoln, RR
    Bucher, P
    Saunders, AM
    Lai, E
    Martin, ER
    Vance, JM
    Oksenberg, JR
    Hauser, SL
    Pericak-Vance, MA
    Haines, JL
    AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (03) : 708 - 717
  • [5] Cytokine profile in relapsing-remitting multiple sclerosis patients and the association between progression and activity of the disease
    Kallaur, Ana Paula
    Oliveira, Sayonara Rangel
    Colado Simao, Andrea Name
    Delicato De Almeida, Elaine Regina
    Morimoto, Helena Kaminami
    Lopes, Josiane
    De Carvalho Jennings Pereira, Wildea Lice
    Andrade, Renato Marques
    Pelegrino, Larissa Muliterno
    Borelli, Sueli Donizete
    Kaimen-Maciel, Damacio Ramon
    Vissoci Reiche, Edna Maria
    MOLECULAR MEDICINE REPORTS, 2013, 7 (03) : 1010 - 1020
  • [6] Analysis of Associations of Polymorphisms of Genes Encoding Cytokine Receptors with the Clinical Features of Multiple Sclerosis
    Kulakova O.G.
    Bashinskaya V.V.
    Tsareva E.Y.
    Boiko A.N.
    Favorova O.O.
    Gusev E.I.
    Neuroscience and Behavioral Physiology, 2018, 48 (3) : 337 - 341
  • [7] The Association Between Apolipoprotein E Genetic Polymorphisms and Multiple Sclerosis
    Tasdemir, Nebahat
    Tamam, Yusuf
    Yalman, Mediha
    NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, 2013, 50 (02): : 110 - 115
  • [8] A meta-analysis of the association between cytokine gene polymorphisms and systemic sclerosis
    Peng, Wen-jia
    Pan, Hai-feng
    Tao, Jin-hui
    Wang, Bing-xiang
    Lu, Man-man
    Wang, Song
    He, Qian
    Wang, Jing
    MODERN RHEUMATOLOGY, 2012, 22 (05) : 695 - 703
  • [9] Interleukin genes polymorphisms in Multiple Sclerosis
    Leon, V. J.
    Caho, J. L.
    Perez, R. Rodriguez
    Sevillano, M. D.
    Gamazo, S.
    Bowakin, D.
    TISSUE ANTIGENS, 2006, 67 (06): : 550 - 550
  • [10] Association of cytokine genes polymorphisms with essential hypertension
    Timasheva, Y.
    Nasibullin, T.
    Zakirova, A.
    Mustafina, O.
    JOURNAL OF HYPERTENSION, 2008, 26 : S139 - S139
12345