Synthesis of Amphiphilic Helix-Coil-Helix Poly(3-(glycerylthio)propyl isocyanate)-block-polystyrene-block-poly(3-(glycerylthio)propyl isocyanate)

被引：11

作者：

Chae, Chang-Geun ^{[1
]}

Seo, Ho-Bin ^{[1
]}

Bak, In-Gyu ^{[1
]}

Lee, Jae-Suk ^{[1
]}

机构：

[1] GIST, Sch Mat Sci & Engn, 123 Cheomdangwagi Ro, Gwangju 61005, South Korea

来源：

MACROMOLECULES | 2018年 / 51卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; LIVING ANIONIC-POLYMERIZATION; HUMAN PRION PROTEIN; FUNCTIONAL POLYMERS; BLOCK-COPOLYMERS; CONFORMATION; METHACRYLATE; VESICLES; TRANSITION; MICELLES;

D O I：

10.1021/acs.macromol.7b02619

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

To achieve molecular packing of protic-functionalized helical polymers in aqueous solution, we synthesized an amphiphilic helix-coil-helix triblock copolymer (triBCP) composed of polystyrene and dihydroxyl-functionalized polyisocyanates. Poly(3-(glycerylthio)propyl isocyanate)-block-polystyrene-block-poly(3-(glycerylthio)propyl isocyanate), P3GPIC-b-PSt-b-P3GPIC, was synthesized by postpolymerization modification. The bidirectional anionic block copolymerization of styrene (St) and allyl isocyanate (AIC) yielded triBCPs, poly(allyl isocyanate)-block-polystyrene-block-poly(allyl isocyanate)s (PAIC-b-PSt-b-PAICs), with well-controlled molecular weights (M-n = 5.60-99.9 kDa) and narrow dispersities (D = 1.14-1.18). Of them, one with the lowest MW (M-n = 5.60 kDa, D = 1.14), which was highly organic-soluble, was utilized in the thiol-ene click reaction between allyl group and 1-thioglycerol, producing P3GPIC-b-PSt-b-P3GPIC. The amphiphilic P3GPIC-b-PSt-b-P3GPIC self-aggregated to form spherical vesicles with an average hydrodynamic diameter of 170 nm in aqueous solution, demonstrating that hydrophilic-helical P3GPIC blocks well interacted with water media maintaining their intermolecular packing.

引用

页码：697 / 704

页数：8