Synthesis of Amphiphilic Helix-Coil-Helix Poly(3-(glycerylthio)propyl isocyanate)-block-polystyrene-block-poly(3-(glycerylthio)propyl isocyanate)

被引：11

作者：

Chae, Chang-Geun ^{[1
]}

Seo, Ho-Bin ^{[1
]}

Bak, In-Gyu ^{[1
]}

Lee, Jae-Suk ^{[1
]}

机构：

[1] GIST, Sch Mat Sci & Engn, 123 Cheomdangwagi Ro, Gwangju 61005, South Korea

来源：

MACROMOLECULES | 2018年 / 51卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; LIVING ANIONIC-POLYMERIZATION; HUMAN PRION PROTEIN; FUNCTIONAL POLYMERS; BLOCK-COPOLYMERS; CONFORMATION; METHACRYLATE; VESICLES; TRANSITION; MICELLES;

D O I：

10.1021/acs.macromol.7b02619

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

To achieve molecular packing of protic-functionalized helical polymers in aqueous solution, we synthesized an amphiphilic helix-coil-helix triblock copolymer (triBCP) composed of polystyrene and dihydroxyl-functionalized polyisocyanates. Poly(3-(glycerylthio)propyl isocyanate)-block-polystyrene-block-poly(3-(glycerylthio)propyl isocyanate), P3GPIC-b-PSt-b-P3GPIC, was synthesized by postpolymerization modification. The bidirectional anionic block copolymerization of styrene (St) and allyl isocyanate (AIC) yielded triBCPs, poly(allyl isocyanate)-block-polystyrene-block-poly(allyl isocyanate)s (PAIC-b-PSt-b-PAICs), with well-controlled molecular weights (M-n = 5.60-99.9 kDa) and narrow dispersities (D = 1.14-1.18). Of them, one with the lowest MW (M-n = 5.60 kDa, D = 1.14), which was highly organic-soluble, was utilized in the thiol-ene click reaction between allyl group and 1-thioglycerol, producing P3GPIC-b-PSt-b-P3GPIC. The amphiphilic P3GPIC-b-PSt-b-P3GPIC self-aggregated to form spherical vesicles with an average hydrodynamic diameter of 170 nm in aqueous solution, demonstrating that hydrophilic-helical P3GPIC blocks well interacted with water media maintaining their intermolecular packing.

引用

页码：697 / 704

页数：8

共 41 条

[1] Synthesis of well-defined rod-coil-rod polyhexylisocyanate-block-polystyrene-block-polyhexylisocyanate via one-pot anionic polymerization [J].

Ahn, JH ;

Lee, JS .

MACROMOLECULAR RAPID COMMUNICATIONS, 2003, 24 (09) :571-575

[2] Synthesis of well-defined block copolymers of n-hexyl isocyanate with isoprene by living anionic polymerization [J].

Ahn, JH ;

Shin, YD ;

Kim, SY ;

Lee, JS .

POLYMER, 2003, 44 (14) :3847-3854

[3] Misfolding pathways of the prion protein probed by molecular dynamics Simulations [J].

Barducci, A ;

Chelli, R ;

Procacci, P ;

Schettino, V .

BIOPHYSICAL JOURNAL, 2005, 88 (02) :1334-1343

[4] Stimuli-responsive polypeptide vesicles by conformation-specific assembly [J].

Bellomo, EG ;

Wyrsta, MD ;

Pakstis, L ;

Pochan, DJ ;

Deming, TJ .

NATURE MATERIALS, 2004, 3 (04) :244-248

[5] Self-Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications [J].

Blanazs, Adam ;

Armes, Steven P. ;

Ryan, Anthony J. .

MACROMOLECULAR RAPID COMMUNICATIONS, 2009, 30 (4-5) :267-277

[6] Development of thermal and photochemical strategies for thiol-ene click polymer functionalization [J].

Campos, Luis M. ;

Killops, Kato L. ;

Sakai, Ryosuke ;

Paulusse, Jos M. J. ;

Damiron, Denis ;

Drockenmuller, Eric ;

Messmore, Benjamin W. ;

Hawker, Craig J. .

MACROMOLECULES, 2008, 41 (19) :7063-7070

[7] Constant-pH Molecular Dynamics Simulations Reveal a β-Rich Form of the Human Prion Protein [J].

Campos, Sara R. R. ;

Machuqueiro, Miguel ;

Baptista, Antonio M. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2010, 114 (39) :12692-12700

[8] Self-assembly of polypeptide-based block copolymer amphiphiles [J].

Carlsen, Autumn ;

Lecommandoux, Sebastein .

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2009, 14 (05) :329-339

[9] In vitro generation of infectious scrapie prions [J].

Castilla, J ;

Saá, P ;

Hetz, C ;

Soto, C .

CELL, 2005, 121 (02) :195-206

[10]

Chae CG, 2015, ANIONIC POLYMERIZATION: PRINCIPLES, PRACTICE, STRENGTH, CONSEQUENCES AND APPLICATIONS, P339, DOI 10.1007/978-4-431-54186-8_7

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