Facile and Scalable Synthesis of Novel Spherical Au Nanocluster Assemblies@Polyacrylic Acid/Calcium Phosphate Nanoparticles for Dual-Modal Imaging-Guided Cancer Chemotherapy

被引:70
作者
Li, Lu [1 ]
Zhang, Lingyu [1 ]
Wang, Tingting [2 ]
Wu, Xiaotong [1 ]
Ren, Hong [1 ]
Wang, Chungang [1 ]
Su, Zhongmin [1 ]
机构
[1] NE Normal Univ, Fac Chem, Changchun 130024, Peoples R China
[2] Changchun Univ Sci & Technol, Sch Chem & Environm Engn, Changchun 130022, Peoples R China
基金
中国国家自然科学基金;
关键词
Au nanoclusters; calcium phosphate; cancer therapy; dual-modal imaging; polyacrylic acid; MESOPOROUS SILICA NANOPARTICLES; ANTICANCER DRUG-DELIVERY; IN-VIVO; GOLD NANOPARTICLES; CALCIUM PHOSPHATES; THERAPY; RELEASE; CORE; PARTICLES; PLATFORM;
D O I
10.1002/smll.201403517
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Engineering novel theranostic agents with both imaging and therapeutic functions have profound impact on molecular diagnostics, imaging, and therapeutics. In this paper, we develop for the first time a simple, scalable, and reproducible route to synthesize novel multifunctional spherical Au nanoclusters assemblies encapsulated by a polyacylic acid (PAA)/calcium phosphate (CaP) shell with aggregation enhanced fluorescence property (designated as AuNCs-A@PAA/CaP). Furthermore, the resulting AuNCs-A@PAA/CaP nanoparticles (NPs) possess a high payload of doxorubicin as synergetic pH-sensitive drug delivery vehicles to employ for dual-modal computed tomography (CT) and fluorescence imaging-guided liver cancer chemotherapy in vivo. The results reveal that AuNCs-A@PAA/CaP NPs not only provide excellent bimodal CT and fluorescence contrast imaging but also present efficient tumor ablation under the guidance of CT and fluorescence imaging, to achieve excellent chemotherapeutic efficacy to the hepatocarcinoma cell line (H-22) bearing mice through intravenous injection. Comprehensive blood tests and careful histological examinations reveal no apparent toxicity of AuNCs-A@PAA/CaP NPs. Our work highlights the great promise of AuNCs-A@PAA/CaP NPs for guiding and monitoring the chemotherapeutic process using simultaneous dual-modality CT and fluorescence imaging through a single theranostic agent.
引用
收藏
页码:3162 / 3173
页数:12
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