The Glutamatergic Neurotransmission in the Central Nervous System

被引：53

作者：

Marmiroli, P. ^{[1
]}

Cavaletti, G. ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Neurosci & Biomed Technol, I-20900 Monza, MB, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2012年 / 19卷 / 09期

关键词：

Central nervous system; excitatory; excitotoxicity; glutamate; peripheral nervous system; receptors; transporters; AMINO-ACID TRANSPORTER; OLIGODENDROCYTE PRECURSOR CELLS; BERGMANN GLIAL-CELLS; VESICULAR GLUTAMATE; RECEPTOR CHANNELS; CA2+ PERMEABILITY; NMDA RECEPTORS; MOLECULAR CHARACTERIZATION; SIGNAL-TRANSDUCTION; PRINCIPAL NEURONS;

D O I：

10.2174/092986712799462711

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system. This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system.

引用

页码：1269 / 1276

页数：8

共 118 条

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