Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana

被引：14
作者：
Karunakaran, Thiruventhan [1 ]
Ee, Gwendoline C. L. [1 ]
Tee, Keng H. [1 ]
Ismail, Intan S. [1 ,2 ]
Zamakshshari, Nor H. [1 ]
Peter, Waziri M. [3 ]
机构：
[1] Univ Putra Malaysia, Dept Chem, Fac Sci, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia, Inst Biosience, Lab Nat Prod, Serdang 43400, Selangor, Malaysia
[3] Univ Putra Malaysia, Inst Biosci, Makna Canc Res Lab, Serdang 43400, Selangor, Malaysia
来源：
PHYTOCHEMISTRY LETTERS | 2016年 / 17卷
关键词：
Mesua beccariana; Coumarin; Xanthone; Cytotoxic; INHIBITORY-ACTIVITY; FERREA; 4-PHENYLCOUMARINS; PYRANOXANTHONES; CONGESTIFLORA; BARK;
D O I：
10.1016/j.phytol.2016.07.026
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested against two cancer cell lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTT assays. Mesuarianone (3) gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT-29 cell line. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：131 / 134
页数：4
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