Polymeric iodophors with poly(2-ethyl-2-oxazoline) and poly (N-vinylpyrrolidone): optical, hydrodynamic, thermodynamic, and antimicrobial properties

被引:9
作者
Makhayeva, Danelya N. [1 ]
Filippov, Sergey K. [2 ,3 ]
Yestemes, Sanzhar S. [1 ]
Irmukhametova, Galiya S. [1 ]
Khutoryanskiy, Vitaliy V. [1 ,2 ]
机构
[1] Al Farabi Kazakh Natl Univ, Dept Chem & Chem Technol, Alma Ata 050040, Kazakhstan
[2] Univ Reading, Sch Pharm, Reading RG6 6DX, Berks, England
[3] Abo Akad Univ, Fac Sci & Engn, Pharmaceut Sci Lab, Turku 20520, Finland
关键词
Iodine; Iodophors; Polymers; Poly(N-vinylpyrrolidone); Poly(2-ethyl-2-oxazoline); Antimicrobial properties; POVIDONE-IODINE; THERMORESPONSIVE POLYMERS; POLYVINYLPYRROLIDONE; POLY(2-OXAZOLINE)S; NANOPARTICLES; PERMEABILITY; COMPLEXES; DIFFUSION; MICELLES; HALOGEN;
D O I
10.1016/j.eurpolymj.2022.111005
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Formation of iodophors by interactions of poly(2-ethyl-2-oxazoline) and poly(N-vinylpyrrolidone) with molecular iodine dissolved in aqueous solutions with addition of potassium iodide and ethanol has been studied using a range of physicochemical techniques including UV-Vis spectroscopy, viscometry, dynamic light scattering, isothermal titration calorimetry and partitioning through semi-permeable membrane. It was established that poly(2-ethyl-2-oxazoline) exhibits greater ability to bind iodine compared to poly(N-vinylpyrrolidone). Despite the difference in the binding ability of these two polymers, their iodophors exhibited similar antimicrobial properties.
引用
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页数:10
相关论文
共 66 条
[1]   Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: Formulation, miscibility, in vitro and in vivo studies [J].
Abilova, Guzel K. ;
Kaldybekov, Daulet B. ;
Ozhmukhametova, Elvira K. ;
Saimova, Aisulu Zh. ;
Kazybayeva, Diara S. ;
Irmukhametova, Galiya S. ;
Khutoryanskiy, Vitaliy V. .
EUROPEAN POLYMER JOURNAL, 2019, 116 :311-320
[2]   Probing the Mucoadhesive Interactions Between Porcine Gastric Mucin and Some Water-Soluble Polymers [J].
Albarkah, Yasser A. ;
Green, Rebecca J. ;
Khutoryanskiy, Vitaliy V. .
MACROMOLECULAR BIOSCIENCE, 2015, 15 (11) :1546-1553
[3]  
BELLER H, 1955, Patent No. 2706701
[4]   INCREASED BACTERICIDAL ACTIVITY OF DILUTE PREPARATIONS OF POVIDONE-IODINE SOLUTIONS [J].
BERKELMAN, RL ;
HOLLAND, BW ;
ANDERSON, RL .
JOURNAL OF CLINICAL MICROBIOLOGY, 1982, 15 (04) :635-639
[5]   Povidone iodine in wound healing: A review of current concepts and practices [J].
Bigliardi, Paul Lorenz ;
Alsagoff, Syed Abdul Latiff ;
El-Kafrawi, Hossam Yehia ;
Pyon, Jai-Kyong ;
Wa, Chad Tse Cheuk ;
Villa, Martin Anthony .
INTERNATIONAL JOURNAL OF SURGERY, 2017, 44 :260-268
[6]   POxylation as an alternative stealth coating for biomedical applications [J].
Bludau, Herdis ;
Czapar, Anna E. ;
Pitek, Andrzej S. ;
Shukla, Sourabh ;
Jordan, Rainer ;
Steinmetz, Nicole F. .
EUROPEAN POLYMER JOURNAL, 2017, 88 :679-688
[7]   Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs [J].
Boel, Eline ;
Smeets, Annelies ;
Vergaelen, Maarten ;
De la Rosa, Victor R. ;
Hoogenboom, Richard ;
Van den Mooter, Guy .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2019, 144 :79-90
[8]   Self-Assembly Thermodynamics of pH-Responsive Amino-Acid-Based Polymers with a Nonionic Surfactant [J].
Bogomolova, Anna ;
Keller, Sandro ;
Klingler, Johannes ;
Sedlak, Marian ;
Rak, Dmytro ;
Sturcova, Adriana ;
Hruby, Martin ;
Stepanek, Petr ;
Filippov, Sergey K. .
LANGMUIR, 2014, 30 (38) :11307-11318
[9]   Study of Complex Thermosensitive Amphiphilic Polyoxazolines and Their Interaction with Ionic Surfactants. Are Hydrophobic, Thermosensitive, and Hydrophilic Moieties Equally Important? [J].
Bogomolova, Anna ;
Filippov, Sergey K. ;
Starovoytova, Larysa ;
Angelov, Borislav ;
Konarev, Petr ;
Sedlacek, Ondrej ;
Hruby, Martin ;
Stepanek, Petr .
JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 118 (18) :4940-4950
[10]   Fitting two- and three-site binding models to isothermal titration calorimetric data [J].
Brautigam, Chad A. .
METHODS, 2015, 76 :124-136