Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals-The FREIA Project

被引:40
作者
van Duursen, Majorie B. M. [1 ]
Boberg, Julie [2 ]
Christiansen, Sofie [2 ]
Connolly, Lisa [3 ]
Damdimopoulou, Pauliina [4 ,5 ]
Filis, Panagiotis [6 ]
Fowler, Paul A. [6 ]
Gadella, Bart M. [7 ]
Holte, Jan [8 ]
Jaager, Kersti [9 ,10 ]
Johansson, Hanna K. L. [2 ]
Li, Tianyi [4 ,5 ]
Mazaud-Guittot, Severine [11 ]
Parent, Anne-Simone [12 ]
Salumets, Andres [9 ,10 ]
Soto, Ana M. [13 ]
Svingen, Terje [2 ]
Velthut-Meikas, Agne [14 ]
Wedebye, Eva Bay [2 ]
Xie, Yuling [3 ]
van den Berg, Martin [7 ]
机构
[1] Vrije Univ Amsterdam, Dept Environm & Hlth, Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands
[2] Tech Univ Denmark, Natl Food Inst, DK-2800 Lyngby, Denmark
[3] Queens Univ Belfast, Sch Biol Sci, Inst Global Food Secur, Belfast BT9 5DL, Antrim, North Ireland
[4] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, SE-14186 Stockholm, Sweden
[5] Karolinska Univ Hosp, SE-14186 Stockholm, Sweden
[6] Inst Med Sci, Sch Med Med Sci & Nutr, Foresterhill, Aberdeen AB23 8ZD, Scotland
[7] Univ Utrecht, Fac Vet Med, Dept Populat Hlth Sci, Yalelaan 2, NL-3584 CM Utrecht, Netherlands
[8] Carl von Linne Clin, Uppsala Sci Pk, S-75183 Uppsala, Sweden
[9] Univ Tartu, Inst Clin Med, Dept Obstet & Gynaecol, Teaduspargi 13, EE-50411 Tartu, Estonia
[10] Competence Ctr Hlth Technol, Teaduspargi 13, EE-50411 Tartu, Estonia
[11] Univ Rennes, INSERM, EHESP, UMR S 1085,Irset, F-35000 Rennes, France
[12] Univ Liege, GIGA Inst, Neuroendocrinol Unit, Ave Hop, B-4000 Liege, Belgium
[13] Tufts Univ, Sch Med, Dept Immunol, Boston, MA USA
[14] Tallinn Univ Technol, Sch Sci, Dept Chem & Biotechnol, EE-12618 Tallinn, Estonia
基金
欧盟地平线“2020”;
关键词
female reproductive health; endocrine disrupting chemicals; test methods; risk assessment; fertility; ovary; oocyte; adrenal; mammary gland; steroidogenesis; bioassay; BISPHENOL-A; ENVIRONMENTAL-INFLUENCES; FOLLICULAR-FLUID; STEROIDOGENESIS; NEUROENDOCRINE; KETOCONAZOLE; DYSGENESIS; EXPOSURE; OVARY; RATS;
D O I
10.3390/ijms21093215
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women's reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman's reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally.
引用
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页数:13
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