Single-Molecular Artificial Transmembrane Water Channels

被引：373

作者：

Hu, Xiao-Bo ^{[1
]}

Chen, Zhenxia ^{[1
]}

Tang, Gangfeng ^{[1
]}

Hou, Jun-Li ^{[1
]}

Li, Zhan-Ting ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 20期

关键词：

HYDROPHILIC MOLECULES; LIPID-BILAYERS; DIFFUSION; MODELS; AQUAPORIN; MEMBRANES; VESICLES; PERMEABILITY; SELECTIVITY; CONDUCTION;

D O I：

10.1021/ja302292c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrazide-appended pillar[5]arene derivatives have been synthesized. X-ray crystal structure analysis and H-1 NMR studies revealed that the molecules adopt unique tubular conformations. Inserting the molecules into the lipid membranes of vesicles leads to the transport of water through the channels produced by single molecules, as supported by dynamic light scattering and cryo-SEM experiments. The channels exhibit the transport activity at a very low channel to lipid ratio (0.027 mol %), and a water permeability of 8.6 X 10(-10) cm s(-1) is realized. In addition, like natural water channel proteins, the artificial systems also block the transport of protons.

引用

页码：8384 / 8387

页数：4

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