Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

被引：43

作者：

Augurusa, Alessandra ^{[1
]}

Mehta, Meera ^{[1
]}

Perez, Manuel ^{[1
]}

Zhu, Jiangtao ^{[1
]}

Stephan, Douglas W. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 82期

基金：

加拿大自然科学与工程研究理事会;

关键词：

TERTIARY AMIDES; ORGANOFLUOROPHOSPHONIUM SALTS; SELF-ENCAPSULATION; SECONDARY AMIDES; SILANE REDUCTION; HYDROGENATION; HYDROSILANES; CARBOXAMIDES; HYDRODEFLUORINATION; ALKYLATION;

D O I：

10.1039/c6cc06914b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.

引用

页码：12195 / 12198

页数：4

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