MicroRNA as tools and therapeutics in lung cancer

被引：109

作者：

Barger, Jennifer F. ^{[1
,2
]}

Nana-Sinkam, S. Patrick ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA

[3] Ohio State Univ, James Comprehens Canc Ctr, Columbus, OH 43210 USA

来源：

RESPIRATORY MEDICINE | 2015年 / 109卷 / 07期

基金：

美国国家卫生研究院;

关键词：

microRNA; Lung; Cancer; EPITHELIAL-MESENCHYMAL TRANSITION; COMPUTED-TOMOGRAPHY; CIRCULATING MICRORNAS; ACQUIRED-RESISTANCE; REDUCED EXPRESSION; CLINICAL-RESPONSE; EGFR REGULATION; CELL CARCINOMA; OVARIAN-CANCER; TUMOR-GROWTH;

D O I：

10.1016/j.rmed.2015.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lung cancer is the number one cause of cancer related deaths. The lack of specific and accurate tools for early diagnosis and minimal targeted therapeutics both contribute to poor outcomes. The recent discovery of microRNAs (miRNAs) revealed a novel mechanism for post-transcriptional regulation in cancer and has created new opportunities for the development of diagnostics, prognostics and targeted therapeutics. In lung cancer, miRNA expression profiles distinguish histological subtypes, predict chemotherapeutic response and are associated with prognosis, metastasis and survival. Furthermore, miRNAs circulate in body fluids and hence may serve as important biomarkers for early diagnosis or stratify patients for personalized therapeutic strategies. Here, we provide an overview of the miRNAs implicated in lung cancer, with an emphasis on their clinical utility. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：803 / 812

页数：10

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