DisseCCTing Phospholipid Function in Lipid Droplet Dynamics

被引:12
作者
Brasaemle, Dawn L. [1 ,2 ]
机构
[1] Rutgers State Univ, Rutgers Ctr Lipid Res, New Brunswick, NJ 08901 USA
[2] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA
关键词
REVEALS;
D O I
10.1016/j.cmet.2011.09.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Phospholipids provide an amphipathic barrier between lipid droplets and the cytoplasm of cells. In this issue of Cell Metabolism, Krahmer and colleagues (2011) define a role for phosphatidylcholine in preventing lipid droplet coalescence and show that the rate-limiting enzyme in phosphatidylcholine synthesis is activated through binding to lipid droplets.
引用
收藏
页码:437 / 438
页数:2
相关论文
共 10 条
[1]   Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic [J].
Bartz, Rene ;
Li, Wen-Hong ;
Venables, Barney ;
Zehmer, John K. ;
Roth, Mary R. ;
Welti, Ruth ;
Anderson, Richard G. W. ;
Liu, Pingsheng ;
Chapman, Kent D. .
JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :837-847
[2]   SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity [J].
Bostrom, Pontus ;
Andersson, Linda ;
Rutberg, Mikael ;
Perman, Jeanna ;
Lidberg, Ulf ;
Johansson, Bengt R. ;
Fernandez-Rodriguez, Julia ;
Ericson, Johanna ;
Nilsson, Tommy ;
Boren, Jan ;
Olofsson, Sven-Olof .
NATURE CELL BIOLOGY, 2007, 9 (11) :1286-U139
[3]   Functional genomic screen reveals genes involved in lipid-droplet formation and utilization [J].
Guo, Yi ;
Walther, Tobias C. ;
Rao, Meghana ;
Stuurman, Nico ;
Goshima, Gohta ;
Terayama, Koji ;
Wong, Jinny S. ;
Vale, Ronald D. ;
Walter, Peter ;
Farese, Robert V., Jr. .
NATURE, 2008, 453 (7195) :657-661
[4]   Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase [J].
Krahmer, Natalie ;
Guo, Yi ;
Wilfling, Florian ;
Hilger, Maximiliane ;
Lingrell, Susanne ;
Heger, Klaus ;
Newman, Heather W. ;
Schmidt-Supprian, Marc ;
Vance, Dennis E. ;
Mann, Matthias ;
Farese, Robert V., Jr. ;
Walther, Tobias C. .
CELL METABOLISM, 2011, 14 (04) :504-515
[5]   Lipolysis - A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores [J].
Lass, Achim ;
Zimmermann, Robert ;
Oberer, Monika ;
Zechner, Rudolf .
PROGRESS IN LIPID RESEARCH, 2011, 50 (01) :14-27
[6]   Phosphatidylcholine and choline homeostasis [J].
Li, Zhaoyu ;
Vance, Dennis E. .
JOURNAL OF LIPID RESEARCH, 2008, 49 (06) :1187-1194
[7]   FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets [J].
Nishino, Naonobu ;
Tamori, Yoshikazu ;
Tateya, Sanshiro ;
Kawaguchi, Takayuki ;
Shibakusa, Tetsuro ;
Mizunoya, Wataru ;
Inoue, Kazuo ;
Kitazawa, Riko ;
Kitazawa, Sohei ;
Matsuki, Yasushi ;
Hiramatsu, Ryuji ;
Masubuchi, Satoru ;
Omachi, Asako ;
Kimura, Kazuhiro ;
Saito, Masayuki ;
Amo, Taku ;
Ohta, Shigeo ;
Yamaguchi, Tomohiro ;
Osumi, Takashi ;
Cheng, Jinglei ;
Fujimoto, Toyoshi ;
Nakao, Harumi ;
Nakao, Kazuki ;
Aiba, Atsu ;
Okamura, Hitoshi ;
Fushiki, Tohru ;
Kasuga, Masato .
JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (08) :2808-2821
[8]   Contribution of each membrane binding domain of the CTP:phosphocholine cytidylyltransferase-α dimer to its activation, membrane binding, and membrane cross-bridging [J].
Taneva, Svetla ;
Dennis, Melissa K. ;
Ding, Ziwei ;
Smith, Jillian L. ;
Cornell, Rosemary B. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (42) :28137-28148
[9]   Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice [J].
Toh, Shen Yon ;
Gong, Jingyi ;
Du, Guoli ;
Li, John Zhong ;
Yang, Shuqun ;
Ye, Jing ;
Yao, Huilan ;
Zhang, Yinxin ;
Xue, Bofu ;
Li, Qing ;
Yang, Hongyuan ;
Wen, Zilong ;
Li, Peng .
PLOS ONE, 2008, 3 (08)
[10]   DGAT enzymes and triacylglycerol biosynthesis [J].
Yen, Chi-Liang Eric ;
Stone, Scot J. ;
Koliwad, Suneil ;
Harris, Charles ;
Farese, Robert V., Jr. .
JOURNAL OF LIPID RESEARCH, 2008, 49 (11) :2283-2301