Mitochondria: In Sickness and in Health

被引：2600

作者：

Nunnari, Jodi ^{[1
]}

Suomalainen, Anu ^{[2
,3
]}

机构：

[1] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA

[2] Univ Helsinki, Biomedicum Helsinki, Res Programs Unit, FIN-00290 Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, Dept Neurol, FIN-00290 Helsinki, Finland

来源：

CELL | 2012年 / 148卷 / 06期

基金：

美国国家卫生研究院; 欧洲研究理事会; 芬兰科学院;

关键词：

ACTIVATED PROTEIN-KINASE; DYNAMIN-RELATED PROTEIN; PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; HEREDITARY OPTIC NEUROPATHY; SUBSTANTIA-NIGRA NEURONS; BROWN ADIPOSE-TISSUE; CYTOCHROME-C RELEASE; INNER MEMBRANE; SKELETAL-MUSCLE; DNA POLYMERASE;

D O I：

10.1016/j.cell.2012.02.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria perform diverse yet interconnected functions, producing ATP and many biosynthetic intermediates while also contributing to cellular stress responses such as autophagy and apoptosis. Mitochondria form a dynamic, interconnected network that is intimately integrated with other cellular compartments. In addition, mitochondrial functions extend beyond the boundaries of the cell and influence an organism's physiology by regulating communication between cells and tissues. It is therefore not surprising that mitochondrial dysfunction has emerged as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders. We provide a current view of how mitochondrial functions impinge on health and disease.

引用

页码：1145 / 1159

页数：15

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