From DNA to Targeted Therapeutics: Bringing Synthetic Biology to the Clinic

被引：30
作者：
Chen, Yvonne Y. [2 ,3 ]
Smolke, Christina D. [1 ]
机构：
[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[2] Harvard Univ, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Syst Biol, Boston, MA 02115 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 106期
关键词：
TAL EFFECTORS; CANCER-CELLS; PROTEINS; EXPRESSION; NUCLEASES; SYSTEMS; TRANSCRIPTION; HOMEOSTASIS; NETWORKS; BACTERIA;
D O I：
10.1126/scitranslmed.3002944
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Synthetic biology aims to make biological engineering more scalable and predictable, lowering the cost and facilitating the translation of synthetic biological systems to practical applications. Increasingly sophisticated, rationally designed synthetic systems that are capable of complex functions pave the way to translational applications, including disease diagnostics and targeted therapeutics. Here, we provide an overview of recent developments in synthetic biology in the context of translational research and discuss challenges at the interface between synthetic biology and clinical medicine.
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页数：5
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