From DNA to Targeted Therapeutics: Bringing Synthetic Biology to the Clinic

被引：30
作者：
Chen, Yvonne Y. [2 ,3 ]
Smolke, Christina D. [1 ]
机构：
[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[2] Harvard Univ, Cambridge, MA 02138 USA
[3] Harvard Univ, Dept Syst Biol, Boston, MA 02115 USA
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 106期
关键词：
TAL EFFECTORS; CANCER-CELLS; PROTEINS; EXPRESSION; NUCLEASES; SYSTEMS; TRANSCRIPTION; HOMEOSTASIS; NETWORKS; BACTERIA;
D O I：
10.1126/scitranslmed.3002944
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Synthetic biology aims to make biological engineering more scalable and predictable, lowering the cost and facilitating the translation of synthetic biological systems to practical applications. Increasingly sophisticated, rationally designed synthetic systems that are capable of complex functions pave the way to translational applications, including disease diagnostics and targeted therapeutics. Here, we provide an overview of recent developments in synthetic biology in the context of translational research and discuss challenges at the interface between synthetic biology and clinical medicine.
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页数：5
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  • [1] Environmentally controlled invasion of cancer cells by engineered bacteria
    Anderson, JC
    Clarke, EJ
    Arkin, AP
    Voigt, CA
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2006, 355 (04) : 619 - 627
  • [2] Synthetic biology: new engineering rules for an emerging discipline
    Andrianantoandro, Ernesto
    Basu, Subhayu
    Karig, David K.
    Weiss, Ron
    [J]. MOLECULAR SYSTEMS BIOLOGY, 2006, 2 (1) : 2006.0028
  • [3] Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing
    Beisel, Chase L.
    Chen, Yvonne Y.
    Culler, Stephanie J.
    Hoff, Kevin G.
    Smolke, Christina D.
    [J]. NUCLEIC ACIDS RESEARCH, 2011, 39 (07) : 2981 - 2994
  • [4] Refinement and standardization of synthetic biological parts and devices
    Canton, Barry
    Labno, Anna
    Endy, Drew
    [J]. NATURE BIOTECHNOLOGY, 2008, 26 (07) : 787 - 793
  • [5] Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems
    Chen, Yvonne Y.
    Jensen, Michael C.
    Smolke, Christina D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (19) : 8531 - 8536
  • [6] Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins
    Culler, Stephanie J.
    Hoff, Kevin G.
    Smolke, Christina D.
    [J]. SCIENCE, 2010, 330 (6008) : 1251 - 1255
  • [7] A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells
    Deans, Tara L.
    Cantor, Charles R.
    Collins, James J.
    [J]. CELL, 2007, 130 (02) : 363 - 372
  • [8] Next-generation optical technologies for illuminating genetically targeted brain circuits
    Deisseroth, Karl
    Feng, Guoping
    Majewska, Ania K.
    Miesenbock, Gero
    Ting, Alice
    Schnitzer, Mark J.
    [J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (41) : 10380 - 10386
  • [9] Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes
    Duan, Faping
    Curtis, Katherine L.
    March, John C.
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008, 74 (23) : 7437 - 7438
  • [10] Interrupting Vibrio cholerae infection of human epithelial cells with engineered commensal bacterial signaling
    Duan, Faping
    March, John C.
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2008, 101 (01) : 128 - 134
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