Plasmodium falciparum:: Interaction of shikimate analogues with antimalarial drugs

被引：15

作者：

McRobert, L

Jiang, SD

Stead, A

McConkey, GA ^{[1
]}

机构：

[1] Univ Leeds, Sch Biol, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Sunderland, Sch Sci, Inst Pharm & Chem, Sunderland SR1 3SD, Durham, England

[3] Tianjin Univ, Coll Pharmaceut & Biotechnol, Dept Med Chem, Tianjin 300072, Peoples R China

来源：

EXPERIMENTAL PARASITOLOGY | 2005年 / 111卷 / 03期

关键词：

shikimate; aromatic; antimalarial; antiparasitic; chemotherapy; drug target; atovaquone; Plasmodium falciparum; malaria; ubiquinone; Apicomplexa; P; falciparum; F-shikimate; fluoro-shikimate;

D O I：

10.1016/j.exppara.2005.07.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The shikimate pathway for aromatic biosynthesis presents a target for antimalarial drug development as this pathway is absent from animals. This study extends previous work on inhibitors of the shikimate pathway, by examining their interaction with the antimalarial drugs pyrimethamine and atovaquone. Combinations of atovaquone with several shikimate analogues exhibited synergistic effects. These findings highlight potential use of shikimate pathway inhibitors in combination therapy. (c) 2005 Elsevier Inc. All rights reserved.

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页码：178 / 181

页数：4

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