Risk Factors for Sporadic Pancreatic Neuroendocrine Tumors: A Case-Control Study

被引:34
作者
Ben, Qiwen [1 ]
Zhong, Jie [1 ]
Fei, Jian [2 ]
Chen, Haitao [3 ]
Yv, Lifen [1 ]
Tan, Jihong [1 ]
Yuan, Yaozong [1 ]
机构
[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gastroenterol, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gen Surg, Shanghai 200025, Peoples R China
[3] Second Mil Med Univ, Changhai Hosp, Dept Geriatr, Shanghai, Peoples R China
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词
DIABETES-MELLITUS; COLORECTAL-CANCER; ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; ENDOCRINE TUMORS; EPIDEMIOLOGY; POLYMORPHISMS; METAANALYSIS; INSULINOMA; MUTATIONS;
D O I
10.1038/srep36073
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The current study examined risk factors for sporadic pancreatic neuroendocrine tumors (PNETs), including smoking, alcohol use, first-degree family history of any cancer (FHC), and diabetes in the Han Chinese ethnic group. In this clinic-based case-control analysis on 385 patients with sporadic PNETs and 614 age-and sex-matched controls, we interviewed subjects using a specific questionnaire on demographics and potential risk factors. An unconditional multivariable logistic regression analysis was used to estimate adjusted odds ratios (AORs). No significant differences were found between patients and controls in terms of demographic variables. Most of the patients with PNETs had well-differentiated PNETs (G1, 62.9%) and non-advanced European Neuroendocrine Tumor Society (ENETS) stage (stage I or II, 83.9%). Ever/heavy smoking, a history of diabetes and a first-degree FHC were independent risk factors for non-functional PNETs. Only heavy drinking was found to be an independent risk factor for functional PNETs (AOR = 1.87; 95% confidence interval [CI], 1.01-3.51). Ever/heavy smoking was also associated with advanced ENETS staging (stage III or IV) at the time of diagnosis. This study identified first-degree FHC, ever/heavy smoking, and diabetes as risk factors for non-functional PNETs, while heavy drinking as a risk factor for functional PNETs.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Environmental risk factors for lung cancer in Iran: a case-control study
    Hosseini, Mostafa
    Naghan, Parisa Adimi
    Karimi, Shirin
    Alinaghi, Seyed Ahmad Seyed
    Bahadori, Moslem
    Khodadad, Kian
    Mohammadi, Forouzan
    Keynama, Kaveh
    Masjedi, Mohammad Reza
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2009, 38 (04) : 989 - 996
  • [42] Environmental and Familial Risk Factors of Parkinsons Disease: Case-Control Study
    Sanyal, Jaya
    Chakraborty, D. P.
    Sarkar, Biswanath
    Banerjee, Tapas Kumar
    Mukherjee, Subhash Chandra
    Ray, Bidhan Chandra
    Rao, V. R.
    CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2010, 37 (05) : 637 - 642
  • [43] Cigarette smoking and the risk of pancreatic cancer: a case-control study
    Wang, Yue
    Duan, Hong
    Yang, Xiaowan
    Guo, Junxi
    MEDICAL ONCOLOGY, 2014, 31 (10)
  • [44] Exploring risk factors linked to canine lymphoma: a case-control study
    Pinello, Katia
    Leite-Martins, Liliana
    Gregorio, Hugo
    Oliveira, Filipe
    Kimura, Katia C.
    Dagli, Maria Lucia Z.
    de Matos, Augusto
    Niza-Ribeiro, Joao
    TOPICS IN COMPANION ANIMAL MEDICINE, 2025, 65
  • [45] Case-control study of risk factors for prostate cancer
    Ilic, M
    Vlajinac, H
    Marinkovic, J
    BRITISH JOURNAL OF CANCER, 1996, 74 (10) : 1682 - 1686
  • [46] Risk factors for keratoconus in Israel: a case-control study
    Gordon-Shaag, Ariela
    Millodot, Michel
    Kaiserman, Igor
    Sela, Tzahi
    Barnett Itzhaki, Guy
    Zerbib, Yaffa
    Matityahu, Efrat
    Shkedi, Shira
    Miroshnichenko, Svetlana
    Shneor, Einat
    OPHTHALMIC AND PHYSIOLOGICAL OPTICS, 2015, 35 (06) : 673 - 681
  • [47] Fiber intake and pancreatic cancer risk: a case-control study
    Bidoli, E.
    Pelucchi, C.
    Zucchetto, A.
    Negri, E.
    Dal Maso, L.
    Polesel, J.
    Boz, G.
    Montella, M.
    Franceschi, S.
    Serraino, D.
    La Vecchia, C.
    Talamini, R.
    ANNALS OF ONCOLOGY, 2012, 23 (01) : 264 - 268
  • [48] Risk factors for diabetic retinopathy: A case-control study
    Lima V.C.
    Cavalieri G.C.
    Lima M.C.
    Nazario N.O.
    Lima G.C.
    International Journal of Retina and Vitreous, 2 (1)
  • [49] Risk factors for gallbladder cancer: A case-control study
    Jain, Kajal
    Sreenivas, V.
    Velpandian, T.
    Kapil, Umesh
    Garg, Pramod Kumar
    INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (07) : 1660 - 1666
  • [50] Risk factors for Japanese encephalitis: a case-control study
    Liu, W.
    Gibbons, R. V.
    Kari, K.
    Clemens, J. D.
    Nisalak, A.
    Marks, F.
    Xu, Z. Y.
    EPIDEMIOLOGY AND INFECTION, 2010, 138 (09) : 1292 - 1297