Running is the neurogenic and neurotrophic stimulus in environmental enrichment

被引：293
作者：
Kobilo, Tali [1 ]
Liu, Qing-Rong [2 ]
Gandhi, Kriti [1 ]
Mughal, Mohammed [3 ]
Shaham, Yavin [2 ]
van Praag, Henriette [1 ]
机构：
[1] NIA, Neuroplast & Behav Unit, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA
[2] NIDA, Behav Neurosci Branch, Intramural Res Program, Baltimore, MD 21224 USA
[3] NIA, Cellular & Mol Neurosci Sect, Neurosci Lab, NIH, Baltimore, MD 21224 USA
来源：
LEARNING & MEMORY | 2011年 / 18卷 / 09期
关键词：
HIPPOCAMPAL NEUROGENESIS; VOLUNTARY EXERCISE; PHYSICAL-EXERCISE; BRAIN; BDNF; PROLIFERATION; ENHANCEMENT; PLASTICITY; INJURY;
D O I：
10.1101/lm.2283011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Environmental enrichment (EE) increases dentate gyrus (DG) neurogenesis and brain-derived neurotrophic factor ( BDNF) levels. However, running is considered an element of EE. To dissociate effects of physical activity and enrichment on hippocampal neurogenesis and BDNF levels, young female C57BI/6 mice were housed under control, running, enrichment, or enrichment plus running conditions, and injected with bromodeoxyuridine. Cell genesis was assessed after 12 d and differentiation was analyzed 1 mo later. In addition, locomotor activity in the open field and hippocampal mature BDNF peptide levels were measured. Open-field adaptation was improved in all groups, compared to controls, but more so with running. New cell proliferation, survival, neuron number, and neurotrophin levels were enhanced only when running was accessible. We conclude that exercise is the critical factor mediating increased BDNF levels and adult hippocampal neurogenesis.
引用
收藏
页码：605 / 609
页数：5
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