Surveillance of duodenal adenomas in familial adenomatous polyposis reveals high cumulative risk of advanced disease

被引:110
作者
Saurin, LC
Gutknecht, C
Napoleon, B
Chavaillon, A
Ecochard, R
Scoazec, JY
Ponchon, T
Chayvialle, JA
机构
[1] Hop Edouard Herriot, Serv Hepatogastroenterol, Federat Specialities Digest, F-69437 Lyon 03, France
[2] Hop Edouard Herriot, Serv Anat Pathol, F-69437 Lyon 03, France
[3] Hosp Civils Lyon, Dept Biostat, Lyon, France
关键词
D O I
10.1200/JCO.2004.06.028
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose The development of high-grade dysplasia (HGD) on duodenal or jejunal adenomas and of late-stage (stage IV) duodenal polyposis are major clinical events for familial adenomatous polyposis (FAP) patients. Our aim was to determine their respective frequency, risk factors, and cumulative risk. Patients and Methods A prospective, optimized, endoscopic surveillance protocol was applied to 58 FAP patients in a university hospital. The number, size, and histology of duodenojejunal polyps were assessed, and the Spigelman's score was calculated at each endoscopy. Cox regression and linear regression analysis were used to determine risk factors for HGD development and the cumulative risk of stage IV duodenal polyposis, respectively. Results During a median (+/- standard deviation) follow-up of 47.9 +/- 15.6 months, 35 patients with at least two consecutive examinations had 107 duodenojejunal examinations. The Spigelman's score increased in 21 patients (60.0%), and HGD developed in 12 patients (34.2%). High initial Spigelman's score (> 7 points), but not age or APC mutation site, was a risk factor for HGD development. Estimated cumulative risk of developing stage IV duodenal polyposis was of 42.9% at age 60 (95% Cl, 35.7% to 50.0%) and 50.0% at age 70 (95% Cl, 42.9% to 57.1%). Conclusion This prospective series shows a higher duodenal polyposis progression rate and cumulative risk of late-stage (stage IV) duodenal polyposis in FAP patients compared with previous series. These results suggest that current modalities for surveillance and management of these patients need revision. (C) 2004 by American Society of Clinical Oncology.
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页码:493 / 498
页数:6
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