Profile of cognitive functioning in women with the fragile X mutation

被引:96
作者
Bennetto, L
Pennington, BF
Porter, D
Taylor, AK
Hagerman, RJ
机构
[1] Univ Rochester, Dept Clin & Social Sci Psychol, Rochester, NY 14627 USA
[2] Univ Denver, Dept Psychol, Denver, CO 80208 USA
[3] Kimball Genet, Denver, CO USA
[4] Childrens Hosp, Child Dev Unit, Denver, CO 80218 USA
[5] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Boulder, CO 80309 USA
关键词
D O I
10.1037//0894-4105.15.2.290
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Two studies tested the specificity of the neurocognitive profile of women with fragile X syndrome (FXS). First, women with an FXS full mutation were compared with women with a premutation and women without FXS who grew up in FXS families. Women with FXS had a significantly lower IQ than the other groups, and analyses of subtest profiles showed they had a relative weakness on Arithmetic and strength on Picture Completion. Women with FXS performed worse than the other groups on executive function, spatial ability, and visual memory. Next, women with FXS were compared with women without FXS matched on age and IQ. A similar IQ profile was found, but women with FXS were worse than controls only on executive function. The authors also examined which neurocognitive indices were related to the underlying biology of the disorder. Overall, the results indicated that executive rather than visuospatial deficits were primary in the neurocognitive profile of FXS.
引用
收藏
页码:290 / 299
页数:10
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