Increase of preproenkephalin mRNA in the caudal part of periaqueductal gray by morphine withdrawal in rats: A quantitative in situ hybridization study

被引：10
作者：
Fukunaga, Y
Nishida, S
Inoue, N
Kishioka, S
Yamamoto, H
机构：
[1] Department of Pharmacology, Wakayama Medical College, Wakayama-City, Wakayama 640
来源：
MOLECULAR BRAIN RESEARCH | 1996年 / 42卷 / 01期
关键词：
naloxone; morphine; withdrawal; preproenkephalin mRNA; periaqueductal gray; hybridization; in situ; rat;
D O I：
10.1016/S0169-328X(96)00158-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effects of morphine withdrawal on the levels of preproenkephalin (PPE) mRNA in the area from lateral to ventrolateral periaqueductal gray (FAG) were studied in rats by quantitative in situ hybridization. PPE mRNA in the rostral FAG was decreased by naloxone-precipitated morphine withdrawal but not affected by spontaneous morphine withdrawal. PPE mRNA in the caudal FAG was increased by both spontaneous and naloxone-precipitated morphine withdrawal.
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页码：128 / 130
页数：3
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