Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect

被引：17

作者：

Guo, Chunfang ^{[1
,2
]}

Liu, Zhaolong ^{[1
]}

Li, Xiangye ^{[1
]}

Han, Xuliang ^{[1
]}

Li, Yueyun ^{[1
]}

Liu, Hui ^{[1
]}

Zhang, Lizhi ^{[1
]}

Li, Xinjin ^{[1
,3
]}

Dong, Yunhui ^{[1
]}

机构：

[1] Shandong Univ Technol, Coll Chem & Chem Engn, 266 West Xincun Rd, Zibo 255000, Peoples R China

[2] Shandong Vocat Coll Light Ind, Zhoucun Mishan Rd, Zibo 255300, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 08期

关键词：

C-H TRIFLUOROMETHYLATION; FLUORINE; DIFLUOROMETHYLATION; PHARMACEUTICALS; ARENES;

D O I：

10.1039/d1cc06466e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive alpha-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail.

引用

页码：1147 / 1150

页数：4

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