Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

被引：10

作者：

Moore, Eli ^{[1
,2
,3
,4
]}

Zill, Andrew T. ^{[2
]}

Anderson, Cyrus A. ^{[2
]}

Jochem, Aljosha R. ^{[5
]}

Zimmerman, Steven C. ^{[2
]}

Bonder, Claudine S. ^{[3
,4
]}

Kraus, Tobias ^{[5
]}

Thissen, Helmut ^{[6
]}

Voelcker, Nicolas H. ^{[1
]}

机构：

[1] Univ South Australia, ARC Ctr Excellence Convergent Bionano Sci & Techn, Future Ind Inst, GPO Box 2471, Adelaide, SA 5001, Australia

[2] Univ Illinois, Dept Chem, 600 S Mathews Ave, Urbana, IL 61801 USA

[3] Univ South Australia, Ctr Canc Biol, Adelaide, SA 5000, Australia

[4] SA Pathol, Adelaide, SA 5000, Australia

[5] Leibniz Inst New Mat, Saabruecken, Germany

[6] CSIRO Mfg Flagship, Bayview Ave, Clayton, Vic 3168, Australia

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2016年 / 217卷 / 20期

关键词：

bioconjugation; click reaction; hyperbranched polymers; LIVING RADICAL POLYMERIZATION; MOLECULAR-WEIGHT; POLYMERS; DENDRIMERS; DERIVATIVES; CHEMISTRY; WATER; GLASS;

D O I：

10.1002/macp.201500507

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights.

引用

页码：2252 / 2261

页数：10

共 50 条

[41] Synthesis and characterization of hyperbranched polyglycerols with various degree of methylation employing phase-transfer conditions
Neumann, Niklas
Boskamp, Laura
Hartwig, Andreas
Koschek, Katharina
POLYMER, 2021, 229
[42] Hyperbranched polyglycerols based iron chelators for iron chelation therapy
ul-Haq, Muhammad Imran
Hamilton, Jasmine L.
Lai, Benjamin F.
Shenoi, Rajesh A.
Kizhakkedathu, Jayachandran N.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
[43] β-Cyclodextrin grafting hyperbranched polyglycerols as carriers for nasal insulin delivery
Zhang, Xuejiao
Zhang, Xinge
Wu, Zhongming
Gao, Xiujun
Shu, Shujun
Wang, Zhen
Li, Chaoxing
CARBOHYDRATE POLYMERS, 2011, 84 (04) : 1419 - 1425
[44] Encapsulation property of hyperbranched polyglycerols as prospective drug delivery systems
Wu, Haigang
Yin, Ting
Li, Ke
Wang, Ruibin
Chen, Yantian
Jing, Lili
POLYMER CHEMISTRY, 2018, 9 (03) : 300 - 306
[45] Antifouling Coatings via Tethering of Hyperbranched Polyglycerols on Biomimetic Anchors
Pranantyo, Dicky
Xu, Li Qun
Neoh, Koon Gee
Kang, En-Tang
Teo, Serena Lay-Ming
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2016, 55 (07) : 1890 - 1901
[46] Optically active amphiphilic hyperbranched polyglycerols as templates for palladium nanoparticles
Chen, Y
Frey, H
Thomann, R
Stiriba, SE
INORGANICA CHIMICA ACTA, 2006, 359 (06) : 1837 - 1844
[47] Synthesis of cyclic polyglycerols
Kawagishi, Takahiro
Yoshikawa, Kimio
Ubukata, Makoto
Hamada, Masahiro
Nakajima, Noriyuki
HETEROCYCLES, 2006, 69 (01) : 107 - +
[48] POLY 431-Employing reversable addition fragmentation chain transfer polymerization to synthesize alkyne-functional amphiphilic diblock copolymers
Bouchard, Addison A.
Sessions, Laura B.
Sundararaman, Anand
Grubbs, Robert B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
[49] In vivo biological evaluation of high molecular weight hyperbranched polyglycerols
Kainthan, Rajesh K.
Brooks, Donald E.
BIOMATERIALS, 2007, 28 (32) : 4779 - 4787
[50] In vitro biological evaluation of high molecular weight hyperbranched polyglycerols
Kainthan, Rajesh Kumar
Hester, Samuel R.
Levin, Elena
Devine, Dana V.
Brooks, Donald Elliott
BIOMATERIALS, 2007, 28 (31) : 4581 - 4590

← 1 2 3 4 5 →