Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

被引：10

作者：

Moore, Eli ^{[1
,2
,3
,4
]}

Zill, Andrew T. ^{[2
]}

Anderson, Cyrus A. ^{[2
]}

Jochem, Aljosha R. ^{[5
]}

Zimmerman, Steven C. ^{[2
]}

Bonder, Claudine S. ^{[3
,4
]}

Kraus, Tobias ^{[5
]}

Thissen, Helmut ^{[6
]}

Voelcker, Nicolas H. ^{[1
]}

机构：

[1] Univ South Australia, ARC Ctr Excellence Convergent Bionano Sci & Techn, Future Ind Inst, GPO Box 2471, Adelaide, SA 5001, Australia

[2] Univ Illinois, Dept Chem, 600 S Mathews Ave, Urbana, IL 61801 USA

[3] Univ South Australia, Ctr Canc Biol, Adelaide, SA 5000, Australia

[4] SA Pathol, Adelaide, SA 5000, Australia

[5] Leibniz Inst New Mat, Saabruecken, Germany

[6] CSIRO Mfg Flagship, Bayview Ave, Clayton, Vic 3168, Australia

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2016年 / 217卷 / 20期

关键词：

bioconjugation; click reaction; hyperbranched polymers; LIVING RADICAL POLYMERIZATION; MOLECULAR-WEIGHT; POLYMERS; DENDRIMERS; DERIVATIVES; CHEMISTRY; WATER; GLASS;

D O I：

10.1002/macp.201500507

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights.

引用

页码：2252 / 2261

页数：10

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