Mitochondria-targeting ratiometric fluorescent probe for γ-glutamyltranspeptidase and its application to colon cancer

被引：35
|
作者：
Park, Seokan [1 ]
Bae, Dong Jun [2 ]
Ryu, Yeon-Mi [2 ]
Kim, Sang-Yeob [2 ,3 ]
Myung, Seung-Jae [2 ,4 ]
Kim, Hae-Jo [1 ]
机构：
[1] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, South Korea
[2] Univ Ulsan, ASAN Inst Life Sci, ASAN Med Ctr, Coll Med, Seoul 138736, South Korea
[3] Univ Ulsan, Dept Convergence Med, Coll Med, Seoul 138736, South Korea
[4] Univ Ulsan, Dept Gastroenterol, Asan Med Ctr, Coll Med, Seoul 138736, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 68期
基金：
新加坡国家研究基金会;
关键词：
MOUSE MODEL; IN-VIVO; TRANSFERASE; GLUTATHIONE; INHIBITOR; GGSTOP; INJURY;
D O I：
10.1039/c6cc05573g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A mitochondria-targeting ratiometric probe was designed for gamma-glutamyltranspeptidase (gamma GT). Mechanistic study by HPLC and an inhibitor assay showed that the probe underwent gamma GT-mediated amide-to-amine transformation and induced a ratiometric fluorescence response in cellular mitochondria. Further application was successful for the detection of cancerous colons in mice.
引用
收藏
页码：10400 / 10402
页数：3
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