Polymers in the prevention of peritoneal adhesions

被引：104

作者：

Yeo, Yoon ^{[2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp,Lab Biomat & Drug Delivery, Div Critical Care Med,Dept Anesthesiol, Boston, MA 02115 USA

[2] Purdue Univ, Weldon Sch Biomed Engn, Sch Pharm & Pharmaceut Sci, W Lafayette, IN 47907 USA

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2008年 / 68卷 / 01期

关键词：

peritoneal adhesions; adhesion barrier; controlled drug delivery; particulate drug delivery system; hydrogels;

D O I：

10.1016/j.ejpb.2007.03.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peritoneal adhesions are serious complications of surgery, and can result in pain, infertility, and potentially lethal bowel obstruction. Pharmacotherapy and barrier devices have reduced adhesion formation to varying degrees in preclinical studies or clinical trials; however, complete prevention of adhesions remains to be accomplished. We and others have hypothesized that the limitations of the two approaches could be overcome by combining their strengths in the context of controlled drug delivery. Here we review the role of polymeric systems in the prevention of peritoneal adhesions, with an emphasis on our recent work in developing and applying polymeric drug delivery systems such as nano- or microparticles, hydrogels, and hybrid systems for peritoneal use. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：57 / 66

页数：10

共 96 条

[21] Evaluation of the SprayGel™ adhesion barrier in the rat cecum abrasion and rabbit uterine horn adhesion models [J].