Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection

被引：235
作者：
Nie, Dan [1 ]
Hu, Yue [1 ]
Chen, Zhou [1 ]
Li, Mingkai [1 ]
Hou, Zheng [1 ]
Luo, Xiaoxing [1 ]
Mao, Xinggang [2 ]
Xue, Xiaoyan [1 ]
机构：
[1] Fourth Mil Med Univ, Dept Pharmacol, Xian, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian, Peoples R China
来源：
JOURNAL OF BIOMEDICAL SCIENCE | 2020年 / 27卷 / 01期
基金：
中国国家自然科学基金;
关键词：
A; baumannii; AbOmpA; Infection; Therapeutic target; Multidrug-resistant; RESISTANT KLEBSIELLA-PNEUMONIAE; BIOFILM FORMATION; ANTIBIOTIC-RESISTANCE; VIRULENCE; GENE; EXPRESSION; PATHOGEN; PURIFICATION; TIGECYCLINE; BACTEREMIA;
D O I：
10.1186/s12929-020-0617-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.
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