Palladium-Catalyzed Ligand-Free Suzuki Reaction of Potassium Aryltrifluoroborates in Aqueous Ethanol

被引：1
|
作者：
Li, Xinmin [1 ]
Liu, Chun [1 ]
Liu, Chao [1 ]
Jin, Zilin [1 ]
机构：
[1] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 36卷 / 06期
基金：
中国国家自然科学基金;
关键词：
palladium; ligand-free; Suzuki reaction; potassium aryltrifluoroborates; aqueous ethanol; CROSS-COUPLING REACTIONS; MIYAURA REACTION; HIGHLY EFFICIENT; BORONIC ACIDS; ARYL; PERSPECTIVES; DERIVATIVES; COMPLEXES;
D O I：
10.6023/cjoc201601001
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and ligand-free protocol has been developed for the Pd(OAc)(2)-catalyzed Suzuki reaction of potassium aryltrifluoroborates in aqueous ethanol under air. In the presence of Pd(OAc)(2) and 1 equiv. of K2CO3, aryl or heteroaryl halides coupled with various potassium aryltrifluoroborates smoothly to afford the products in high yields with the highest turnover frequency (TOF) up to 4656 h(-1), and a series of triphenylamine derivatives were prepared efficiently in this system. In addition, the active catalyst was proved to be the in situ-generated palladium nanoparticles according to TEM analysis and mercury-poisoning test.
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收藏
页码：1341 / 1350
页数：10
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