Application of attenuated coxsackievirus B3 as a viral vector system for vaccines and gene therapy

被引:16
作者
Kim, Dae-Sun [1 ]
Nam, Jae-Hwan [1 ]
机构
[1] Catholic Univ Korea, Dept Biotechnol, Puchon, Gyunggi, South Korea
来源
HUMAN VACCINES | 2011年 / 7卷 / 04期
关键词
coxsackievirus B3; attenuation; recombinant virus; viral vaccine vector; viral gene delivery vector; PARALYTIC POLIOMYELITIS; INTERFERON-GAMMA; DILATED CARDIOMYOPATHY; DISSEMINATED MEASLES; ACUTE-PANCREATITIS; VIRUS-INFECTION; UNITED-STATES; IN-VITRO; MYOCARDITIS; EXPRESSION;
D O I
10.4161/hv.7.4.14422
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Coxsackievirus B3 (CVB3) contains a single-stranded plus-strand RNA genome and belongs to the genus Enterovirus in the family Picornaviridae. For decades, many studies have shown that enteroviruses are potential viral vectors. Of these viruses, polioviruses and coxsackieviruses have predominantly been investigated. Therefore, the molecular biology of these two viruses and the cellular receptors involved in their infection are relatively well known, and infectious cDNAs and proper animal models of their infection are available. CVB3, in particular, will become increasingly important in the development of an enteroviral vector because poliovirus is currently subject to the global poliovirus eradication program. This review highlights the potential use of CVB3 as a viral vector for vaccines and therapeutic gene delivery.
引用
收藏
页码:410 / 416
页数:7
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