Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor

被引：82

作者：

Akishita, M ^{[1
]}

Kozaki, K ^{[1
]}

Eto, M ^{[1
]}

Yoshizumi, M ^{[1
]}

Ishikawa, M ^{[1
]}

Toba, K ^{[1
]}

Orimo, H ^{[1
]}

Ouchi, Y ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Tokyo 1138655, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 251卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.9409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17 beta-estradiol dose dependently inhibited gene expression and peptide secretion of ET-1. This inhibitory effect of 17 beta-estradiol was more marked when ET-1 production was stimulated by transforming growth factor-beta 1. Simultaneous addition of ICI 182,780, a pure estrogen receptor antagonist, completely blocked the effect of 17 beta-estradiol, indicating that 17 beta-estradiol acted via estrogen receptor. These results suggest that reduced ET-1 production by endothelial cells may be involved in the vasoprotective effect of estrogen. (C) 1998 Academic Press.

引用

页码：17 / 21

页数：5

共 36 条

[31]

Spyridopoulos I, 1997, CIRCULATION, V95, P1505

[32] POSTMENOPAUSAL ESTROGEN THERAPY AND CARDIOVASCULAR-DISEASE - 10-YEAR FOLLOW-UP FROM THE NURSES HEALTH STUDY [J].