Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor

被引：82
作者：
Akishita, M [1 ]
Kozaki, K [1 ]
Eto, M [1 ]
Yoshizumi, M [1 ]
Ishikawa, M [1 ]
Toba, K [1 ]
Orimo, H [1 ]
Ouchi, Y [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Tokyo 1138655, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 251卷 / 01期
关键词：
D O I：
10.1006/bbrc.1998.9409
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17 beta-estradiol dose dependently inhibited gene expression and peptide secretion of ET-1. This inhibitory effect of 17 beta-estradiol was more marked when ET-1 production was stimulated by transforming growth factor-beta 1. Simultaneous addition of ICI 182,780, a pure estrogen receptor antagonist, completely blocked the effect of 17 beta-estradiol, indicating that 17 beta-estradiol acted via estrogen receptor. These results suggest that reduced ET-1 production by endothelial cells may be involved in the vasoprotective effect of estrogen. (C) 1998 Academic Press.
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页码：17 / 21
页数：5
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