Effects of transcranial direct current stimulation on the auditory mismatch negativity response and working memory performance in schizophrenia: a pilot study

被引:16
作者
Impey, Danielle [1 ,2 ]
Baddeley, Ashley [1 ]
Nelson, Renee [1 ]
Labelle, Alain [3 ]
Knott, Verner [1 ]
机构
[1] Univ Ottawa, Inst Mental Hlth Res, Clin Neuroelectrophysiol & Cognit Res Lab, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada
[2] Univ Ottawa, Sch Psychol, 136 Jean Jacques Lussier, Ottawa, ON K1N 6N5, Canada
[3] Royal Ottawa Mental Hlth Ctr, Schizophrenia Program, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Transcranial direct current stimulation (tDCS); Auditory discrimination; Event-related potentials (ERPs); Mismatch negativity (MMN); Schizophrenia; Working memory; DORSOLATERAL PREFRONTAL CORTEX; NONINVASIVE BRAIN-STIMULATION; D-ASPARTATE RECEPTORS; CORTICAL NEUROPLASTICITY; BREAKTHROUGH BIOMARKER; MMN; TDCS; HALLUCINATIONS; GENERATION; DEFICITS;
D O I
10.1007/s00702-017-1783-y
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Cognitive impairment has been proposed to be the core feature of schizophrenia (Sz). Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation which can improve cognitive function in healthy participants and in psychiatric patients with cognitive deficits. tDCS has been shown to improve cognition and hallucination symptoms in Sz, a disorder also associated with marked sensory processing deficits. Recent findings in healthy controls demonstrate that anodal tDCS increases auditory deviance detection, as measured by the brain-based event-related potential, mismatch negativity (MMN), which is a putative biomarker of Sz that has been proposed as a target for treatment of Sz cognition. This pilot study conducted a randomized, double-blind assessment of the effects of pre- and post-tDCS on MMN-indexed auditory discrimination in 12 Sz patients, moderated by auditory hallucination (AH) presence, as well as working memory performance. Assessments were conducted in three sessions involving temporal and frontal lobe anodal stimulation (to transiently excite local brain activity), and one control session involving 'sham' stimulation (meaning with the device turned off, i.e., no stimulation). Results demonstrated a trend for pitch MMN amplitude to increase with anodal temporal tDCS, which was significant in a subgroup of Sz individuals with AHs. Anodal frontal tDCS significantly increased WM performance on the 2-back task, which was found to positively correlate with MMN-tDCS effects. The findings contribute to our understanding of tDCS effects for sensory processing deficits and working memory performance in Sz and may have implications for psychiatric disorders with sensory deficits.
引用
收藏
页码:1489 / 1501
页数:13
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