Coating bacteria for anti-tumor therapy

被引：9

作者：

Wang, Jiahui ^{[1
]}

Guo, Ning ^{[1
]}

Hou, Weiliang ^{[1
,2
]}

Qin, Huanlong ^{[1
]}

机构：

[1] Tongji Univ, Dept Gastrointestinal Surg, Shanghai Peoples Hosp 10, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai Key Lab Nucle Acid Chem & Nanomed,Inst M, Shanghai, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

tumor therapy; tumor targeting; coating; bacteria; materials; ORAL DELIVERY; BREAST-CANCER; IN-VITRO; PROBIOTIC BACTERIA; BASIC PRINCIPLES; ALGINATE BEADS; SALMONELLA; DRUG; MICROCAPSULES; ENCAPSULATION;

D O I：

10.3389/fbioe.2022.1020020

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Therapeutic bacteria have shown great potential on anti-tumor therapy. Compared with traditional therapeutic strategy, living bacteria present unique advantages. Bacteria show high targeting and great colonization ability in tumor microenvironment with hypoxic and nutritious conditions. Bacterial-medicated antitumor therapy has been successfully applied on mouse models, but the low therapeutic effect and biosafe limit its application on clinical treatment. With the development of material science, coating living bacteria with suitable materials has received widespread attention to achieve synergetic therapy on tumor. In this review, we summarize various materials for coating living bacteria in cancer therapy and envision the opportunities and challenges of bacteria-medicated antitumor therapy.

引用

页数：12

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