Effectiveness of Lanzhou lamb rotavirus vaccine against rotavirus gastroenteritis requiring hospitalization: A matched case-control study

被引:78
作者
Fu, Chuanxi [1 ]
Wang, Ming [1 ]
Liang, Jianhua [1 ]
He, Tongjie [2 ]
Wang, Dahu [1 ]
Xu, Jianxiong [1 ]
机构
[1] Guangzhou Ctr Dis Control & Prevent, Guangzhou, Peoples R China
[2] Guangzhou Childrens Hosp, Guangzhou, Peoples R China
关键词
rotavirus; vaccine effectiveness; acute gastroenteritis;
D O I
10.1016/j.vaccine.2007.10.036
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We sought to determine the vaccine effectiveness (VE) of Lanzhou lamb rotavirus (LLR) vaccine against rotavirus gastroenteritis in children <5 requiring hospitalization. Children hospitalized 2002-2004 with rotavirus gastroenteritis were matched by gender, age and community to 838 controls. VE was calculated for one or more doses of LLR vaccine with 95% confidence intervals (Q. For one dose versus zero doses, LLR vaccine VE was 73.3% (95% CI, range 61.2-81.6%). VE of one dose versus zero doses was higher in children 12-23 months than in children 2-11 months (80.9% versus 60.0%). We found one dose moderately effective in preventing rotavirus gastroenteritis requiring hospitalization. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:8756 / 8761
页数:6
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