Spontaneous neoplastic lesions in aged Sprague-Dawley rats

被引：41

作者：

Nakazawa, M ^{[1
]}

Tawaratani, T ^{[1
]}

Uchimoto, H ^{[1
]}

Kawaminami, A ^{[1
]}

Ueda, M ^{[1
]}

Ueda, A ^{[1
]}

Shinoda, Y ^{[1
]}

Iwakura, K ^{[1
]}

Kura, K ^{[1
]}

Sumi, N ^{[1
]}

机构：

[1] Nippon Shinyaku Co Ltd, Res Labs, Minami Ku, Kyoto 6018550, Japan

来源：

EXPERIMENTAL ANIMALS | 2001年 / 50卷 / 02期

关键词：

rats; spontaneous tumor; Sprague-Dawley;

D O I：

10.1538/expanim.50.99

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76. 7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.

引用

页码：99 / 103

页数：5

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