Antidiabetic activity of a xanthone compound, mangiferin

被引：169
|
作者：
Miura, T
Ichiki, H
Hashimoto, I
Iwamoto, N
Kato, M
Kubo, M
Ishihara, E
Komatsu, Y
Okada, M
Ishida, T
Tanigawa, K
机构：
[1] Suzuka Univ Med Sci, Suzuka, Mie 5100293, Japan
[2] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan
[3] Tsumura & Co, Tsumura Cent Res Labs, Ami, Ibaraki, Japan
来源：
PHYTOMEDICINE | 2001年 / 8卷 / 02期
关键词：
mangiferin; KK-Ay mice; antidiabetic activity; insulin resistance;
D O I：
10.1078/0944-7113-00009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.
引用
收藏
页码：85 / 87
页数：3
相关论文
共 50 条
  • [31] Antidiabetic activity of isoquercetin in diabetic KK -Ay mice
    Zhang, Rui
    Yao, Yang
    Wang, Yingping
    Ren, Guixing
    NUTRITION & METABOLISM, 2011, 8
  • [32] Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship
    Dar, A
    Faizi, S
    Naqvi, S
    Roome, T
    Zikr-ur-Rehman, S
    Ali, M
    Firdous, S
    Moin, ST
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (04) : 596 - 600
  • [33] Antidiabetic Activity of Nyctanthes Arbortristis
    Nanu, Rathod
    Raghuveer, I
    Chitme, H. R.
    Chandra, Ramesh
    PHARMACOGNOSY MAGAZINE, 2008, 4 (16) : 335 - 340
  • [34] First report on mangiferin (C-glucosyl-xanthone) isolated from leaves of a wild coffee plant, Coffea pseudozanguebariae (Rubiaceae)
    Talamond, Pascale
    Mondolot, Laurence
    Gargadennec, Annick
    de Kochko, Alexandre
    Hamon, Serge
    Fruchier, Alain
    Campa, Claudine
    ACTA BOTANICA GALLICA, 2008, 155 (04) : 513 - 519
  • [35] Electroanalytical Application of Amine-grafted Attapulgite to the Sensitive Quantification of the Bioactive Compound Mangiferin
    Tchieno, Francis Merlin Melataguia
    Sonfack, Leopoldine Guenang
    Ymele, Ervice
    Ngameni, Emmanuel
    Tonle, Ignas Kenfack
    ELECTROANALYSIS, 2017, 29 (02) : 529 - 537
  • [36] Acute and 28-day subchronic toxicity studies of mangiferin, a glucosyl xanthone isolated from Mangifera indica L. stem bark
    Prado, Yalena
    Merino, Nelson
    Acosta, Jhoany
    Herrera, Jose A.
    Luque, Yilian
    Hernandez, Ivones
    Prado, Elisa
    Garrido, Gabino
    Delgado, Rene
    Rodeiro, Idania
    JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH, 2015, 3 (01): : 13 - 23
  • [37] Improving liposolubility and lipid antioxidant activity of mangiferin through esterification by lipase
    Yu, Xin
    Yang, Xinyi
    Qian, Junqing
    Guo, Hui
    EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2024, 126 (04)
  • [38] Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice
    Yao, Yang
    Chen, Feng
    Wang, Mingfu
    Wang, Jiashi
    Ren, Guixing
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (19) : 8869 - 8873
  • [39] Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
    Ozbek, Hanefi
    Acikara, Ozlem Bahadir
    Keskin, Ilknur
    Kirmizi, Neriman Ipek
    Ozbilgin, Serkan
    Oz, Burcin Ergene
    Kurtul, Ekin
    Ozrenk, Bade Cevriye
    Tekin, Mehmet
    Saltan, Gulcin
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 86 : 172 - 176
  • [40] Can Statin be a Novel Pharmacophore for Antidiabetic Activity ?
    Parmar, S. A.
    Mehta, A. A.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2009, 9 (12) : 1423 - 1428
12345