Antidiabetic activity of a xanthone compound, mangiferin

被引：169
|
作者：
Miura, T
Ichiki, H
Hashimoto, I
Iwamoto, N
Kato, M
Kubo, M
Ishihara, E
Komatsu, Y
Okada, M
Ishida, T
Tanigawa, K
机构：
[1] Suzuka Univ Med Sci, Suzuka, Mie 5100293, Japan
[2] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan
[3] Tsumura & Co, Tsumura Cent Res Labs, Ami, Ibaraki, Japan
来源：
PHYTOMEDICINE | 2001年 / 8卷 / 02期
关键词：
mangiferin; KK-Ay mice; antidiabetic activity; insulin resistance;
D O I：
10.1078/0944-7113-00009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.
引用
收藏
页码：85 / 87
页数：3
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