Antidiabetic activity of a xanthone compound, mangiferin

被引：176

作者：

Miura, T

Ichiki, H

Hashimoto, I

Iwamoto, N

Kato, M

Kubo, M

Ishihara, E

Komatsu, Y

Okada, M

Ishida, T

Tanigawa, K

机构：

[1] Suzuka Univ Med Sci, Suzuka, Mie 5100293, Japan

[2] Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan

[3] Tsumura & Co, Tsumura Cent Res Labs, Ami, Ibaraki, Japan

来源：

PHYTOMEDICINE | 2001年 / 8卷 / 02期

关键词：

mangiferin; KK-Ay mice; antidiabetic activity; insulin resistance;

D O I：

10.1078/0944-7113-00009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.

引用

页码：85 / 87

页数：3

共 9 条

[1] ROLE OF OVARIAN HORMONES IN THE LONG-TERM CONTROL OF GLUCOSE-HOMEOSTASIS - EFFECTS ON INSULIN-SECRETION [J].