Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment

被引：48
作者：
Baglin, TP [1 ]
机构：
[1] Addenbrookes NHS Trust, Dept Haematol, Cambridge CB2 2QQ, England
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2001年 / 54卷 / 04期
关键词：
heparin induced thrombocytopenia; thrombosis; immune complexes; platelet aggregating factor;
D O I：
10.1136/jcp.54.4.272
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Heparin induced thrombocytopenia thrombosis (HIT/T) is associated with a high morbidity and mortality. Diagnosis is essentially clinical and negative results of laboratory assays do not exclude the diagnosis. Treatment involves stopping all heparin immediately and giving an alternative thrombin inhibitor. The adoption of low molecular weight heparins is one reason for the reduced incidence of this disease in recent years.
引用
收藏
页码：272 / 274
页数：3
相关论文
共 32 条
  • [1] Reduced morbidity and mortality rates of the heparin-induced thrombocytopenia syndrome
    Almeida, JI
    Coats, R
    Liem, TK
    Silver, D
    [J]. JOURNAL OF VASCULAR SURGERY, 1998, 27 (02) : 309 - 314
  • [2] AMIRAL J, 1992, THROMB HAEMOSTASIS, V68, P95
  • [3] Heparin-induced thrombocytopenia:: New insights into the impact of the FcγRIIa-R-H131 polymorphism
    Carlsson, LE
    Santoso, S
    Baurichter, G
    Kroll, H
    Papenberg, S
    Eichler, P
    Westerdaal, NAC
    Kiefel, V
    van de Winkel, JGJ
    Greinacher, A
    [J]. BLOOD, 1998, 92 (05) : 1526 - 1531
  • [4] CHONG BH, 1993, THROMB HAEMOSTASIS, V69, P344
  • [5] ANNOTATION - HEPARIN-INDUCED THROMBOCYTOPENIA
    CHONG, BH
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1995, 89 (03) : 431 - 439
  • [6] IMMUNE ENDOTHELIAL-CELL INJURY IN HEPARIN-ASSOCIATED THROMBOCYTOPENIA
    CINES, DB
    TOMASKI, A
    TANNENBAUM, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (10) : 581 - 589
  • [7] DAVIDSON S, 1997, THROMB HAEMOST S, V79, P283
  • [8] DAVIDSON S, 1999, THROMB HAEMOST S, V82, P452
  • [9] GEORGE J, 1996, THROMBOSIS ITS DISOR, P359
  • [10] LABORATORY DIAGNOSIS OF HEPARIN-ASSOCIATED THROMBOCYTOPENIA AND COMPARISON OF PLATELET-AGGREGATION TEST, HEPARIN-INDUCED PLATELET ACTIVATION TEST, AND PLATELET FACTOR-4 HEPARIN ENZYME-LINKED-IMMUNOSORBENT-ASSAY
    GREINACHER, A
    AMIRAL, J
    DUMMEL, V
    VISSAC, A
    KIEFEL, V
    MUELLERECKHARDT, C
    [J]. TRANSFUSION, 1994, 34 (05) : 381 - 385
1234