Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice

被引：20

作者：

Jeong, Mi Sook ^{[2
]}

Choi, Sun Eun ^{[1
]}

Kim, Ji Young ^{[2
]}

Kim, Jung Shim ^{[2
]}

Kim, Eun Joo ^{[2
]}

Park, Kwan Hee ^{[1
]}

Lee, Do Ik ^{[1
]}

Joo, Seong Soo ^{[3
]}

Lee, Chung Soo ^{[2
]}

Bang, Hyoweon ^{[2
]}

Lee, Mi-Kyung ^{[2
]}

Choi, Young Wook ^{[2
]}

Li, Kap-sok ^{[2
]}

Moon, Nam Ju ^{[2
]}

Lee, Min Won ^{[1
]}

Seo, Seong Jun ^{[2
]}

机构：

[1] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea

[2] Chung Ang Univ, Coll Med, Dept Dermatol, Seoul 156756, South Korea

[3] Gangneung Wonju Natl Univ, Div Marine Mol Biotechnol, Kangnung 210702, Gangwon, South Korea

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2010年

关键词：

ALNUS-JAPONICA; NITRIC-OXIDE; DIARYLHEPTANOIDS; EXPRESSION; EXTRACT; BARKS;

D O I：

10.1155/2010/618517

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.

引用

页数：7

共 33 条

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