A genetic study of the acute anxious response to carbon dioxide stimulation in man

被引:42
作者
Battaglia, Marco
Ogliari, Anna
Harris, Jennifer
Spatola, Chiara A. M.
Pesenti-Gritti, Paola
Reichborn-Kjennerud, Ted
Torgersen, Svenn
Kringlen, Einar
Tambs, Kristian
机构
[1] Univ Vita Salute San Raffaele, Ist Sci San Raffaele, Dept Psychol, I-20127 Milan, Italy
[2] Ist Sci Eugenio Medea, Dept Child Psychiat, I-23842 Bosisio Parini, Italy
[3] Univ Laval, CRULRG, Dept Psychiat, Quebec City, PQ G1K 7P4, Canada
[4] Norwegian Inst Publ Hlth, Div Epidemiol, N-0403 Oslo, Norway
[5] Norwegian Inst Publ Hlth, Div Mental Hlth, N-0403 Oslo, Norway
[6] Univ Oslo, Inst Psychiat, N-0316 Oslo, Norway
[7] Univ Oslo, Dept Psychol, N-0317 Oslo, Norway
关键词
panic; carbon dioxide; twins; genetics; endophenotypes; suffocation;
D O I
10.1016/j.jpsychires.2006.12.002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
People with panic disorder-agoraphobia and their relatives often react anxiously to CO2-enriched gas mixtures. Available data are not suited to disentangle genetic from common environmental causes of familial aggregation Of CO2 reactivity, nor provide quantitative estimations of the sources of trait variation. Three-hundred-forty-six twin pairs belonging to the general population-based Norwegian NIPH Mental Health Study underwent self-assessments of anxiety and of DSM-IV panic symptoms after inhalation of a 35%CO2-65%O-2 mixture. Two thresholds were employed at sample's 75th and 90th percentiles of responses - to define provoked panic attacks and to calculate polychoric correlations. Variance components were estimated by structural equation modelling (SEM). For definitions of responses based on the sum of all 13 panic symptoms, SEM could not discriminate between shared environmental versus genetic causes of familial resemblance for provoked attacks. For definitions of responses based on global anxiety, or on the sums of those symptoms (dyspnea, dizziness, palpitations) with highest variance Post-CO2, the best-fitting models indicated additive genetic factors as the sole causes for within-family resemblance. Best-fit heritability estimates ranged from 0.42 to 0.57. Genetic and idiosyncratic environmental factors explain most of individual differences in reactivity to hypercapnia. Within-family similarities for this trait are largely explained by genetic determinants. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:906 / 917
页数:12
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