Thiaisatoic anhydrides: Efficient synthesis under microwave heating conditions and study of their reactivity.

被引：22

作者：

Fabis, F

Jolivet-Fouchet, S

Robba, M

Landelle, H

Rault, S

机构：

[1] Ctr Etud & Rech Medicament Normandie, F-14032 Caen, France

[2] Univ Caen, Syntheval SA, F-14032 Caen, France

来源：

TETRAHEDRON | 1998年 / 54卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(98)00636-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-thiaisatoic anhydride 1 and 3-thiaisatoic anhydride 2 were synthesized in large scale under microwave heating conditions with 85% and 67% yields respectively. The reactivity of these two compounds was studied towards various nucleophiles and appeared to be generally different from that of isatoic anhydride : many new thiophene-2 and 3-carboxylic acids were isolated with good yields as potential new pharmacological scaffolds. (C) 1998 Elsevier Science Ltd. AU rights reserved.

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页码：10789 / 10800

页数：12

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