Alkyl glycosides as potential anti-Candida albicans growth agents

被引：4

作者：

Klunda, Tomas ^{[1
]}

Machova, Eva ^{[1
]}

Cizova, Aalzbeta ^{[1
]}

Horak, Radim ^{[2
]}

Polakova, Monika ^{[1
]}

Bystricky, Slavomir ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, Bratislava 84538, Slovakia

[2] Palacky Univ, Dept Organ Chem, Tr 17 Listopadu 12, Olomouc 77146, Czech Republic

来源：

CHEMICAL PAPERS | 2016年 / 70卷 / 09期

关键词：

susceptibility; synthetic glycosides; Candida albicans;

D O I：

10.1515/chempap-2016-0051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Candida infections are becoming increasingly prevalent and many clinical isolates are resistant to common azole derivatives treatment. Accordingly, the capacity of a series of 19 alkyl glycosides, mainly mannosides and glucosides but also a cellobioside with aglycone chain-length from C-6 to C-20, to inhibit the growth of laboratory and clinically isolated strains of Candida albicans, was investigated. The study showed that only glycosides with the C-10 and C-12 aglycones were effective growth inhibitors of both types of Candida strains, whose metabolic activity was also significantly reduced as revealed by an XTT assay. (c) 2016 Institute of Chemistry, Slovak Academy of Sciences

引用

页码：1166 / 1170

页数：5

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