Mechanisms of metal ion-dependent oxidation of human low density lipoprotein

被引：10

作者：

Lynch, SM ^{[1
]}

Frei, B ^{[1
]}

机构：

[1] BOSTON UNIV, SCH MED, WHITAKER CARDIOVASC INST, BOSTON, MA 02118 USA

来源：

JOURNAL OF NUTRITION | 1996年 / 126卷 / 04期

关键词：

copper; iron; free radicals; atherosclerosis; human;

D O I：

10.1093/jn/126.suppl_4.1063S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Although either copper or iron is essential for oxidation of human low density lipoprotein (LDL) by vascular cells, the mechanism is unknown. In our experiments copper- and iron-mediated LDL oxidation was found to proceed by different mechanisms. Oxidation of LDL by iron requires superoxide and proceeds by a hydroxyl radical-independent mechanism involving reduction of iron from the ferric to the ferrous form. In contrast, copper-mediated LDL oxidation involves direct reduction of copper from the cupric to the cuprous form by LDL.

引用

页码：S1063 / S1066

页数：4

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