Sensitization of Non-small Cell Lung Cancer Cells to Cisplatin by Naturally Occurring Isothiocyanates

被引：41

作者：

Di Pasqua, Anthony J. ^{[1
]}

Hong, Charles ^{[1
]}

Wu, Mona Y. ^{[1
]}

McCracken, Erin ^{[1
]}

Wang, Xiantao ^{[1
]}

Mi, Lixin ^{[1
]}

Chung, Fung-Lung ^{[1
]}

机构：

[1] Georgetown Univ, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2010年 / 23卷 / 08期

关键词：

GLUTATHIONE; SULFORAPHANE; CHEMOTHERAPY; CYTOTOXICITY; PACLITAXEL; APOPTOSIS; MECHANISM; BINDING; AGENTS; E-4IB;

D O I：

10.1021/tx100187f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We show that naturally occurring isothiocyanates (ITCs) sensitize human non-small cell lung cancer cells to cisplatin. Moreover, the structure of the ITC side chain moiety is important for sensitization. In NCI-H596 cells, 20 mu M benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) enhance the efficacy of various concentrations of cisplatin, but sulforaphane (SFN) does not. Reducing the concentration of BITC and PEITC to 10 mu M still allows for the sensitization of cells to cisplatin. Neither cellular platinum accumulation nor DNA platination account for this increased cytotoxicity. BITC and PEITC deplete beta-tubulin, but SFN does not; this correlates with and may be important for sensitization.

引用

页码：1307 / 1309

页数：3

共 30 条

[1] The discovery and development of cisplatin [J].

Alderden, RA ;

Hall, MD ;

Hambley, TW .

JOURNAL OF CHEMICAL EDUCATION, 2006, 83 (05) :728-734

[2] Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations [J].

Bodo, J. ;

Hunakova, L. ;

Kvasnicka, P. ;

Jakubikova, J. ;

Duraj, J. ;

Kasparkova, J. ;

Sedlak, J. .

BRITISH JOURNAL OF CANCER, 2006, 95 (10) :1348-1353

[3]

Bodo J, 2005, NEOPLASMA, V52, P510

[4] Biomolecular Targets for Platinum Antitumor Drugs [J].

Bose, Rathindra N. .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2002, 2 (02) :103-111

[5] Isothiocyanates as cancer chemopreventive agents: Their biological activities and metabolism in rodents and humans [J].

Conaway, CC ;

Yang, YM ;

Chung, FL .

CURRENT DRUG METABOLISM, 2002, 3 (03) :233-255

[6]

Dabrowiak J., 2009, METALS MED

[7] Role of carbonate in the cytotoxicity of carboplatin [J].

Di Pasqua, Anthony J. ;

Goodisman, Jerry ;

Kerwood, Deborah J. ;

Toms, Bonnie B. ;

Dubowy, Ronald L. ;

Dabrowiak, James C. .

CHEMICAL RESEARCH IN TOXICOLOGY, 2007, 20 (06) :896-904

[8]

Duraj J, 2009, NEOPLASMA, V56, P208

[9] Sulforaphane protects against cisplatin-induced nephrotoxicity [J].

Enrique Guerrero-Beltran, Carlos ;

Calderon-Oliver, Mariel ;

Tapia, Edilia ;

Medina-Campos, Omar N. ;

Javier Sanchez-Gonzalez, Dolores ;

Maria Martinez-Martinez, Claudia ;

Mariana Ortiz-Vega, Karla ;

Franco, Martha ;

Pedraza-Chaverri, Jose .

TOXICOLOGY LETTERS, 2010, 192 (03) :278-285

[10] The influence of temperature on antiproliferative effects, cellular uptake and DNA platination of the clinically employed Pt(II)-drugs [J].

Gabano, Elisabetta ;

Colangelo, Donato ;

Ghezzi, Anna Rita ;

Osella, Domenico .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102 (04) :629-635

← 1 2 3 →