Direct synthesis of 1,1'-[1,4-phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD 3100) without the use of protecting groups

被引：11
|
作者：
Achmatowicz, M [1 ]
Hegedus, LS [1 ]
机构：
[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 16期
关键词：
D O I：
10.1021/jo030146r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A four-step synthesis of the title compound starting from methyl acrylate, ethylenediamine, and dimethyl malonate is reported. The synthesis can be run on a multigram scale and is operationally simple. The use of protecting groups is avoided by utilizing the trioxocyclam as the key coupling intermediate.
引用
收藏
页码：6435 / 6436
页数：2
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