AKTivation mechanisms

被引：34

作者：

Cole, Philip A. ^{[1
,2
]}

Chu, Nam ^{[1
,2
]}

Salguero, Antonieta L. ^{[1
,2
,3
]}

Bae, Hwan ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Genet, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[3] Johns Hopkins Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2019年 / 59卷

关键词：

C-TERMINAL TAIL; PROTEIN-KINASE; AKT; AKT/PKB; PHOSPHORYLATION; ACTIVATION; TARGET; GROWTH;

D O I：

10.1016/j.sbi.2019.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Akt1-3 (Akt) are a subset of the AGC protein Ser/Thr kinase family and play important roles in cell growth, metabolic regulation, cancer, and other diseases. We describe some of the roles of Akt in cell signaling and the biochemical and structural mechanisms of the regulation of Akt catalysis by the phospholipid PIP3 and by phosphorylation. Recent findings highlight a diverse set of strategies to control Akt catalytic activity to ensure its normal biological functions.

引用

收藏

页码：47 / 53

页数：7

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